SERUM THERAPY IN DIPHTHERIA.

Danish contributions to the evaluation of serum therapy for diphtheria in the 1890s.

Characterization of serum anti-diphtheria antibody activity following administration of equine anti-toxin for suspected diphtheria

There is a global shortage of equine-derived diphtheria anti-toxin (DAT) for diphtheria treatment. There are few existing data on serum antibody concentrations and neutralizing activity post-treatment to support development of new therapeutics. Antibody concentrations were quantified by ELISA and anti-toxin neutralizing activity by cytotoxicity assay in serum from 4 patients receiving DAT for s...

Intercostal Herpes Zoster Treated with Diphtheria Anti-Toxic Serum

Diphtheria

Gentlemen,?I have occasionally heard a man, about to read a paper upon some subject, commence by expressing his sense of his unfitness for the task he has undertaken. I have, I must confess, looked upon this appeal, ad misericordiam, with much suspicion, believing the writer, did he not in his own heart believe himself particularly well-fitted for the work, would not have undertaken it. To-day,...

Access to diphtheria antitoxin for therapy and diagnostics.

The most effective treatment for diphtheria is swift administration of diphtheria antitoxin (DAT) with conjunct antibiotic therapy. DAT is an equine immunoglobulin preparation and listed among the World Health Organization Essential Medicines. Essential Medicines should be available in functioning health systems at all times in adequate amounts, in appropriate dosage forms, with assured quality...